Brain-derived neurotrophic factor or in short BDNF is among the neurotrophic factors which encourage differentiation, maturation, and survival of neurons in the nervous system and reveals that a neuroprotective effect under adverse conditions ,for example glutamatergic stimulation, cerebral ischemia, hypoglycemia, and neurotoxicity.
BDNF stimulates and regulates development of neurons from neural stem cells (neurogenesis) and BDNF protein and mRNA are identified in many brain regions such as the olfactory bulb, cortex, hippocampus, basal forebrain, mesencephalon, hypothalamus, brainstem and spinal cord. The degree of quantitate human BDNF are diminished in several neurodegenerative diseases.
In people, it's also within blood platelets in which it accumulates after its biosynthesis in megakaryocytes. BDNF levels are therefore easily detectable in human serum and it's been speculated they may somehow function as a sign of brain functioning. BDNF amounts can be quantified in human serum, these amounts are rather stable within one year.
The Individual BDNF ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and pee. The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p. BDNF is a part of the neurotrophin family of growth factors.
Individual BDNF ELISA kit was used to ascertain the results of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. Additionally, it has been used to ascertain the plasma BDNF levels in GD1 patients and control inhabitants. Variation in the BDNF gene expression changes these neurological purposes.
BDNF also plays a very important role in cardiovascular function and participates in angiogenesis through the particular receptor tropomyosin-related kinase B (TrkB). It's included in the pathogenesis of Alzheimer's ′s disorder. Pro BDNF interacts with p75 neurotrophin receptor, Resulting in long-term depression in the hippocampus.